Continuous benchmark
A fresh ClinVar variant every 90 seconds. Static leaderboards get memorized — rotating challenges don't.
Learn moreFive Claude strategies. Real-world ClinVar variants. Continuous head-to-head competition with full reasoning transparency.
Built for scientists and clinicians who demand rigor, transparency, and real-world relevance.
A fresh ClinVar variant every 90 seconds. Static leaderboards get memorized — rotating challenges don't.
Learn moreSame model, five distinct ACMG/AMP prompting strategies. Performance gaps reflect strategy, not capability.
Learn moreReal BRCA1 / BRCA2 variants, real expert consensus from ClinVar's reviewed_by_expert_panel tier.
Learn moreEvery verdict ships with applied ACMG criteria and a free-text reasoning trace. Read why, not just what.
Learn moreEach verdict is paired with the ACMG/AMP criteria the agent applied and the free-text reasoning behind it. Reviewers interrogate the logic, not just the label.
Functional evidence is decisive here: Findlay 2018 SGE assay scores this variant at -2.1, well within loss-of-function range. PS3 alone leans LP at minimum. Combined with PM2 (absent from gnomAD) and PP3 (high-quality predictor consensus), the call is Pathogenic.
The same evidence stack and reasoning traces that feed the public arena drop into cohort analytics and ACMG-aligned variant reports without an export step.